However, a relatively high prevalence of irreversible memory impairment (21% for PCI, 0% for observation) and fatigue (21% for PCI, 7% for observation) were reported at two years. ![]() Most adverse events occurred within the first year after randomization and seemed reversible as most of them were no longer reported at two years after randomization. Position-paper-Idiopathische-Pulmonale-Fibrose Januari 2014. ![]() The number of patients with mild (grade 1 or 2) adverse events was relatively high, but comparable between PCI and observation. The Dutch Working Party on Antibiotic Policy in collaboration with the Dutch Association of Chest Physicians, the Dutch Society for Intensive Care and the Dutch College of General Practitioners have updated their evidence-based guidelines on the diagnosis and treatment of community-acquired pneumonia (CAP) in adults who present to the hospital. Background: The NVALT-11/DLCRG-02 randomized phase III study compared PCI to. Although the observed OS benefit of PCI was small and not statistically significant, PCI was demonstrated to be beneficial in terms of PFS and BMFS. Locally Advanced NSCLC Volume 13, ISSUE 4, SUPPLEMENT, S60, April 2018. You can follow him as ttscoff on Twitter, GitHub. Brett is a writer and developer living in Minnesota, USA. I’ll update if others reach its level, but for right now, if you’re an nvALT user or take a lot of notes in general, I highly recommend grabbing it (2.99 US on iTunes). Post-hoc sample size computation showed that more than 14,000 patients and 3100 deaths in total would be needed to detect a statistically significant 2% OS difference at 80% power (two sided). But 1Writer has developed into a truly great companion for nvALT. Conducting and adding a new RCT to the present IPD would most likely further narrow the 95% CI, but given the homogeneity of the results of the most recent trials and the marginal effect of adding another trial being likely minor, the observed HR of 0.90 and 5-year absolute benefit of 1.8% would most likely not change considerably. One cycle of: 5-fluorouracil, 300 mg/m 2 on days 1–4 vincristine, 2.0 mg on day 1 mitomycin C, 10 mg/m 2 on day 1 cyclophosphamide, 400 mg/m 2 on day 29 doxorubicin, 40 mg/m 2 on day 29 and cisplatin, 40 mg/m 2 on day 29Īt least two cycles of docetaxel, or paclitaxel, or vinorelbine and carboplatin or a cisplatin-based regimenģ0 or 37.5 Gy in 15 fractions concomitant with loco-regional treatmentģ0 Gy in 15 fractions after loco-regional and systemic treatmentģ0 Gy in 10 fractions after loco-regional and systemic treatmentģ6 Gy in 18 fractions or 30 Gy in 12 or 10 fractions after loco-regional and systemic treatmentīy pooling the updated IPD of all available phase III trials, we could analyze the data of more patients with higher statistical power and a longer follow-up than the published trials. Type and number of cycles of chemotherapy Eén van de oplossingen is zorgen dat mensen langer in goede gezondheid leven, met meer eigen regie en met behulp van technologie. Met de steeds groter wordende druk op de zorg staan we voor een grote maatschappelijke uitdaging. Surgery with pre- or postoperative radiotherapy and/or chemotherapyĬoncurrent chemotherapy and radiotherapy alone or with induction chemotherapy and/or surgery. Zes PPS-consortia ontvangen financiering voor onderzoek naar zorg in de eigen leefomgeving. Radiotherapy alone or with neoadjuvant, adjuvant or concurrent chemotherapy. Radiotherapy alone or sequential chemotherapy and radiotherapy Type and timing of loco-regional and/or systemic treatment Minimization (centrally) after loco-regional and systemic treatment Stratified block randomization (centrally) after loco-regional and systemic treatment At later time-points, except for significantly better cognitive functioning at 24 months in the observational arm (median 83 vs 67, p = 0.017), no significantly different QoL (either QLQ-C30 or EQ-5D) was observed between the two arms.Centrally (exact method unknown) before loco-regional and systemic treatment ![]() At three months, QLQ-C30 showed that physical functioning, cognitive functioning, and global disease specific QoL were significantly better in the observational arm (median 83 vs 73, p = 0.003, median 100 vs 83, p = 0.006 and median 67 vs 67, p = 0.017). At three months, the observational arm scored significantly better on the EQ-VAS (median 70 vs 60, p = 0.017), while EQ-5D utility scores (Dutch tariff) were similar. Baseline QoL was similar between both arms, except for emotional (p = 0.025) and cognitive functioning (p = 0.039) which showed a significantly better score in the PCI arm. Results: In total, 86 and 88 patients were included in the PCI and observational arm respectively, accumulating to 853 observations (five observations completely missing).
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